![]() However, even highly conserved functional sites can present a wide spectrum of amino acids. interacting) sites whose location is more highly conserved are also more conserved in their type of amino acid. Resultsįunctional sites were extracted from experimentally determined structural complexes from the Protein Data Bank harbouring a conserved protein domain from the SMART database. In the analysis presented here, we have investigated the conservation of location and type of amino acids at functional sites, and compared the behaviour of functional sites between different protein domains. ![]() Most available methods are based on a set of homologous sequences and structural or evolutionary information, and assume that functional sites are more conserved than the average. Accordingly, accurate methods for the prediction of functional sites are of immense value. The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design.
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